Be bio-resistant to produce engineered B-cells for rare diseases

Be Biopharma signed strategic partnership with National Resilience for the production of engineered B cells, a new class of cellular therapies for rare diseases.

As part of the collaboration, the alliance will advance on Be Bio’s initial rare disease programs.

Be Bio’s B Cell Medicines (BeCM) platform uses the potential of the human B cell to develop a new class of autologous and allogeneic cell therapies that generate therapeutic proteins in vivo without the need for toxic preconditioning.

Companies will invest to drive innovation and consistency in the production of cell therapy, which is a vital factor for significant impact on patients.

Under the deal, Resilience will provide personnel for the production and delivery of a viral vector and a GMP cell therapy medicinal product for the initial programs in the Be Bio Rare Diseases Pipeline.

Resilience will handle production costs and is eligible to receive potential stage payments and royalties in the future, under a creative cost model and risk sharing.

In addition, the company will monitor the clinical production of GMP of a viral vector and a cell therapy drug for Be Be’s initial rare disease programs for first human clinical trials.

To carry out this process, Resilience will use its bioprocessing solutions and network of cell therapy facilities, including those at Research Triangle Park, Philadelphia, Waltham and Marlborough.

Be Bio CEO Joan Smith-Farrell said: “Production is critical to the rapid movement of our BeCMs to the clinic, and we have built GMP-compliant production facilities at our Cambridge facility.

“This deal allows us to manage GMP production with an exclusive partner and in a cost-effective way.

“Resilience’s extensive manufacturing capabilities, strong collaboration spirit and dedicated resources on our platform make them an ideal partner for our BeCM programs.”

In April this year, Resilience and Opus Genetics signed a strategic manufacturing services agreement to develop the production of adeno-associated viral vector-based gene therapies for inherited retinal diseases.

The coverage for cell and gene therapy in pharmaceutical technology is maintained by Cytiva.

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