A research team has developed a risk assessment based on individuals’ genetic data to predict their likelihood of needing hip or knee replacement surgery for osteoarthritis. The ability to predict the outcome was confirmed in a study published in Arthritis and rheumatology.

The result includes 10 variants of the genetic sequence for predicting the risk of a person in need of knee replacement surgery and 37 variants of the genetic sequence for predicting the risk of the need for hip replacement surgery.

Among 12,093 individuals of European genetic origin aged ≥70 years, 1,422 (11.8%) had knee replacement and 1,297 (10.7%) had hip prostheses. Participants with high risk outcomes had 1.44 times higher chances of knee replacement and 1.88 times higher chances of hip replacement compared to those with low risk outcomes.

“Genetic outcomes like the one we developed don’t change in a person’s life. They provide the individual with additional information about their risk of severe osteoarthritis later in life and have the potential to improve the prevention of severe osteoarthritis of the knee and hip by identifying those who may benefit from early intervention, ”said senior author Flavia. Chikutini, PhD, from Monash University in Australia.

Reference journal:

Lakaz, P., et al. (2022) Genomic risk of advanced osteoarthritis in the elderly. Arthritis and rheumatology. doi.org/10.1002/art.42156.

The story first appeared in News Medical

Genetic risk score has potential to improve prevention of severe knee and hip osteoarthritis

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