Intestinal epithelial cells remain active in mice even after the irritant or infection has cleared, which may be a source of chronic intestinal pain associated with irritable bowel syndrome.


May 6, 2022

Light micrographic image of a section of the small intestine


Chronic intestinal pain in people with irritable bowel syndrome (IBS) may be due to long-term activation of rare intestinal cells. In mice, these cells continue to respond to stimuli even after the substances have left the gut.

IBS affects up to 15% of the US population and is two to six times more common in women than in men. The condition is characterized by symptoms such as bloating, abdominal pain and hypersensitivity to certain foods and irritants, although …

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